Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report.

Author(s): Murgia, Cinzia; Orru, Marisa; Portoghese, Elaine; Garau, Nicoletta; Zedda, Pierina; Berria, Rachele; Motzo, Costantino; Sulis, Simonetta; Murenu, Michela; Paoletti, Anna Maria; Melis, Gian Benedetto

Source: Reprod Biol Endocrinol Volume: 6 Pages: 24 Published: 2008

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Abstract: BACKGROUND: We previously reported a high prevalence (22.3%) of gestational diabetes mellitus (GDM) in a large group of Sardinian women, in contrast with the prevalence of Type 2 diabetes. Sardinia has an unusual distribution of haplotypes and genotypes, with the highest population frequency of HLA DR3 in the world, and after Finland, the highest prevalence of Type 1 diabetes and Autoimmune-related Diseases. In this study we preliminarily tested the prevalence of serological markers of Type 1 diabetes in a group of Sardinian GDM patients. METHODS: We determined glutamic decarboxylase antibodies (anti-GAD65), protein tyrosine phosphatase ICA 512 (IA2) antibodies (anti-IA2), and IAA in 62 GDM patients, and in 56 controls with matching age, gestational age and parity. RESULTS: We found a high prevalence and very unusual distribution of antibodies in GDM patients (38.8%), the anti-IA2 being the most frequent antibody. Out of all our GDM patients, 38.8% (24 of 62) were positive for at least one antibody. Anti-IA2 was present in 29.0 % (18 out of 62) vs. 7.1% (4 out of 56) in the controls (P < p =" NS)." p =" 0.04)" class="hitHilite">diabetes.

PubMed ID: 18588707

Document Type: Journal Article; Research Support, Non-U.S. Gov't

Language: English

Address: Dipartimento Chirurgico Materno Infantile e di Scienza delle Immagini, Sezione di Clinica Ginecologica, Ostetrica e Fisiopatologia della Riproduzione Umana, Universita' degli Studi di Cagliari, Italy. cinziamurgia@tiscali.it

Citation Subset: Index Medicus

ISSN: 1477-7827

NLM Unique ID: 101153627

Country: England

Date Created: 14 Jul 2008

Published Electronically: 29 Jun 2008